The Science
Hydration that works
beneath the surface
Most serums moisturize. Hydra Depth Serum hydrates — at every layer of your skin, simultaneously.
Your skin holds up to 10,000mg of hyaluronic acid naturally — but daily exposure to UV, stress, and environmental aggressors depletes it faster than your body can replenish it. The result isn't just dryness. It's a gradual collapse of the structural scaffolding that keeps skin plump, smooth, and resilient.
One molecule can only
reach one depth
Hyaluronic acid molecules come in different sizes. Large molecules cannot pass through the skin barrier. Small molecules penetrate deeply but don't hydrate the surface. Most serums use only one form — which means they're only solving part of the problem.
Each molecule was chosen
for a specific depth
High Molecular Weight Hyaluronic Acid
~1,000–1,800 kDa · Surface LayerThe largest HA molecule forms an invisible, breathable film on the skin's surface. It binds atmospheric moisture and locks existing hydration in — reducing transepidermal water loss (TEWL) and creating the immediate plumping and softness felt from first application.
Immediate surface hydration + plumpingRef. 1, 2
Sodium Hyaluronate Crosspolymer
Cross-linked · Stratum CorneumA crosslinked form of hyaluronic acid designed for extended residence time on the skin. Unlike standard HA which disperses quickly, crosspolymer creates a hydration reservoir within the outer skin layers — releasing moisture gradually over time and maintaining softness throughout the day.
Extended-release hydration reservoirRef. 3
Sodium Hyaluronate
~10–300 kDa · EpidermisThe salt form of hyaluronic acid is smaller, more stable, and more bioavailable than standard HA. It penetrates through the stratum corneum into the viable epidermis — attracting and binding up to 1,000 times its weight in water at a cellular level, plumping the skin from within.
Epidermal water-binding + plumpingRef. 1, 4
Hydrolyzed Hyaluronic Acid
<10 kDa · Deep DermisThe smallest HA fragment achieves the deepest penetration — reaching the dermis where collagen and elastin live. At this depth, hydrolyzed HA stimulates fibroblast activity and encourages the skin's natural production of new hyaluronic acid, creating long-term structural improvement over time.
Deep dermal hydration + HA synthesisRef. 5, 6
What peer-reviewed research shows
Molecular weight determines penetration depth
Research using Raman spectroscopy confirmed that low-molecular-weight HA (<50 kDa) penetrates significantly deeper into the skin than high-molecular-weight HA, which remains at the surface. This validated the multi-weight approach as clinically superior to single-form serums.
Essendoubi et al., Skin Research and Technology, 2016 — Ref. 2Topical HA improves skin hydration, elasticity, and firmness
A 2022 literature review found consistent evidence that topical hyaluronic acid formulations significantly improve skin hydration parameters, reduce wrinkle depth, and increase skin elasticity — with low-molecular-weight forms showing superior results for anti-aging markers.
Bravo et al., Dermatologic Therapy, 2022 — Ref. 4Multi-weight formulations outperform single-weight serums
A clinical study comparing cream formulations of different HA molecular weights found that combining multiple molecular weights produced significantly better anti-wrinkle outcomes than single-weight formulations — addressing both surface and deeper skin layers simultaneously.
Pavicic et al., Journal of Drugs in Dermatology, 2011 — Ref. 3Nano-HA stimulates endogenous hyaluronic acid production
Nano-sized hyaluronic acid (<10 kDa) applied topically was shown to penetrate into the dermis and stimulate fibroblasts to increase natural HA synthesis — meaning continued use supports the skin's own capacity to stay hydrated, not just temporary surface-level moisture.
Jegasothy et al., Journal of Clinical and Aesthetic Dermatology, 2014 — Ref. 6Formulated without anything your skin doesn't need
References
Papakonstantinou E, Roth M, Karakiulakis G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258. https://doi.org/10.4161/derm.21923
Essendoubi M, Gobinet C, Reynaud R, et al. (2016). Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Skin Research and Technology, 22(1), 55–62. https://doi.org/10.1111/srt.12228
Pavicic T, Gauglitz GG, Lersch P, et al. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology, 10(9), 990–1000.
Bravo B, Correia P, Gonçalves Junior JE, Sant'Anna B, Kerob D. (2022). Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From the literature to clinical practice. Dermatologic Therapy, 35(12), e15903. https://doi.org/10.1111/dth.15903
Necas J, Bartosikova L, Brauner P, Kolar J. (2008). Hyaluronic acid (hyaluronan): a review. Veterinarni Medicina, 53(8), 397–411.
Jegasothy SM, Zabolotniaia V, Bielfeldt S. (2014). Efficacy of a new topical nano-hyaluronic acid in humans. Journal of Clinical and Aesthetic Dermatology, 7(3), 27–29.